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It is recommended the drug be diluted with an equal volume of either Sterile Water for injection, USP, Normal Saline, or 5% Dextrose in Water.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.16 years and older: See adult dosing Data not available Data not available -The individual response is somewhat varied depending on the dose, route of administration, and age of patient, so that the dosage recommendation cannot be absolutely fixed.The drug should be titrated against the patient's requirements.More rapid administration may result in respiratory depression and enhanced pressor response.
Reconstitution advice: -The 100 mg/m L concentration should not be injected IV without proper dilution.
Bath application of 50 μM histamine induced a depolarization which could be attributed to reduction of a background voltage-independent “leakage” potassium current: the depolarization was associated with an increase in apparent input resistance, under voltage clamp its reversal potential approximated the potassium reversal potential, and the histamine-induced current exhibited little voltage dependence.
The pharmacology of the histamine-induced depolarization of human cortical neurons was studied by use of both agonists and antagonists.
-The larger the total dose, the longer will be complete recovery.
-Because of rapid induction following the initial IV injection, the patient should be in a supported position during administration.